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ACNE/ROSACEA



  DEMODEXIN - Unresponsive chronic acne/rosacea anti-parasite lotion - 4 oz.
Code: DMDX-04
Price: $50.00
Quantity in Basket: none

If you or someone you know has had persistent, unresponsive acne/rosacea symptoms characterized by blotchy skin which transmigrates around the face accompanied by itchiness or a tickling sensation then the problem is facial mites (Demodex folliculorum and Demodex brevis). Demodex brevis is the type that is usually the cause of deep-seated, long-term problems associated with facial acne/rosacea and scarring. Scarring may accompany this condition along with a residual bacterial infection caused by the detritus of mite infestation for long-term sufferers.

1. What are Demodex mites?

Demodex Mites, also known as face mites, are not so well known by the public. They are parasites which live on the face and in the hair follicles of humans. They can badly damage the facial skin of humans, usually starting at middle age when the immune system is weakened and their population has increased.

There are two existing types: the longer kind, Demodex folliculorum, which live in the hair follicles and the short ones, Demodex brevis, which live in the sebaceous glands.

The mites are invisible to the naked eye, usually measuring between 100 – 300 microns in length.

2. Where do Demodex live?

The mites can live on all body parts wherever there are hair roots and sebaceous glands. However, they are most prevalent in the facial area, especially the nose, forehead, chin, and cheeks. These areas have the most favorable living and breeding conditions and provide an optimum temperature for them to thrive.

The Demodex folliculorum mite can also live in the eye lash roots and can be the reason for blepharitis, itching and infections. The hair follicles from the scalp are also often infected with itching as a result.

The mouth of these mites is like a very sharp needle that can directly sting into the cells to absorb nutrition. They like a wet and warm environment and become the most active in the dark. There are five stages in the life cycle. After mating on the surface of the skin, they go back into it and lay eggs, taking bacteria with them and excreting wastes and secretions, laying eggs and dying within its layers. After death, their corpses become liquid and decompose inside the skin.

The Parasite

Demodex is usually 100 – 300 microns long. In simple terms it is smaller than the tiniest insect but bigger than a germ.

There are two types, the long and the short. Parasitizing the facial sebaceous glands at an appropriate temperature, Demodexes reproduce by a generation every 15 days. The adult Demodex die soon after the reproduction and the bodies rot and liquidate inside the sebaceous glands. Since Demodex spend all their lives inside the sebaceous glands, they physically and chemically affect the skin, reducing its immune competence, and causing allergic reactions in some parts of skin tissues, where red spots (acne) breaks out. This is sometimes known as adolescent acne for obvious reasons.

If not treated properly with correct medication, the inflammation will reoccur. In more serious cases, the epidermis, or the appearance of skin, will be permanently injured, scars resembling the texture of orange skin will be left, hair follicle pores will be enlarged, and the skin will become thicker due to hyperplasia. Sometimes, the inflammation even leads to superfluous tumors or lumps, and red nose.

What hinders the permeation of medicine is the membrane enclosing the eggs of Demodex?

Therefore, patients are required to apply the lotions continuously, without any intervals, until a seborrhea test shows negative, which indicates a full recovery.

Generally, victims of superficial Demodex rosacea caused by the long Demodex mites should use the lotion for 120 – 180 days, while patients of deep Demodex rosacea caused by the short Demodex mites should use the lotion for 180 – 360 days.

The therapies must go on to the end, even if the symptom of inflammation disappears a few days after first using the lotion. Demodexin will clear the face usually within a few days but less than 1 week. There will be a great deal of excretions and migration during the intial treatment period. Do not be alarmed by this.

Those who are found to have Demodex existing in their skin but do not yet suffer from acarodermatitis may effectively prevent themselves from contracting the disease by applying the lotion.

According to the research, once the human body is infected, the Demodex will become parasitic, mainly in the sebum of the hair follicles of the face where body touch is frequent, the sebaceous glands are well developed and the temperature is perfect. They absorb nourishment, excrete wastes, copulate and lay eggs. Within 15 days, they give birth to a new generation, the mites die, rot and liquefy in the skin.

As the Demodex complete the entirety of their life cycle in the sebum glands and hair follicles, they cause mechanical and chemical stimulation to the skin. More and more stimulation will produce an allergic reaction that leads to inflammation such as popular eruption, pustules, etc. which we all know as acne and even erythema.

If this situation is not followed by correct diagnosis and treatment, the mites will increasingly multiply and the inflammation will get worse, leaving scars on the face, the damaged pores accompanied with widening of the capillaries, thicker skin, hyperplasis and worse, there might be vegetation or pimples which will spoil the skin.

What damage can Demodex do?

Demodex mites live inside the sebaceous glands and hair follicles, sucking nutrients from the hair roots and damaging the cell walls. After mating they burrow into the skin, laying eggs, introducing bacteria and infection to the skin. Throughout the five phases of their life cycle, these mites destroy the skin by excreting wastes and secretions, laying eggs and dying within its layers. After death, their corpses become liquid and decompose inside the skin.

Research indicates that human Demodex is a conditional-pathogenic parasite. The disorder occurs as the result of a large infestation of Demodex mites on the skin, combined with a weakened immune system. The physical, chemical and mechanical stimulation of the skin from the mites can cause the immune system to react in extreme ways. Local allergic inflammation, erythema, papules and pustules are all reactions by the immune system.

The adolescent mite dermatitis and early symptoms of rosacea are frequently misdiagnosed as adolescent acne. A sample study has shown that from people with mite dermatitis (at least 60% of the population), 2.44% have rosacea; 7.56% have acne-like mite dermatitis. When mite testing and the accorded treatment are not carried out, this condition causes increased damage to the normal health, structure and beauty of the skin. The destruction of the skin becomes more and more severe as the condition persists, leaving the facial skin rough and ugly.

The inflammation will repeatedly occur without timely intervention, correct diagnosis and effective therapy. Pathologic changes to the skin, such as enlarged opening of the hair follicles, widened pores, enlarged and damaged capillaries, hyperplasia of cells and even rhinophyma (growth of the nose and central facial areas) can develop. Given this, it is not difficult to imagine the extent of the damage that the mites cause.

What are the most obvious signs from Demodex activity?

There are numerous different signs of Demodex activity. This is not a complete list, rather it contains some of the most common cases.

One of the most obvious signs of the condition is a itching, crawling sensation on the face or (and) in the scalp, but most of the time, there is no itching at all, and people are not aware they are infested with Demodex mites. Often, the pores on the nose, forehead, chin and cheeks become visibly larger. At a further stage, acne can develop; after some time, the facial skin can become red in places (rosacea,) enlarging and damaging the capillaries, thickening the nose (brandy nose), etc.

Tickling sensation on the face. This occurs most frequently on the lower nose, forehead and cheeks, especially in the evening and night. This is the highest period of activity, usually when they mate. Many people are not aware of this tickle, because it starts gradually and it becomes an automatic reaction to scratch without noticing. You may have observed someone repeatedly scratching their face without realizing it.

Tickle on the scalp. Naturally, there can be also other conditions that give cause for scratching, like lice and dandruff. These should be ruled out in order to determine proper treatment.

Hair loss. In some cases, premature hair loss can be linked with extended Demodex folliculorum activity.

Widened pores. Starts usually on the nose and cheeks.

Acne. Forms include pimples, pustules, papules, popular eruption etc.

Red skin. Usually appears on the lower sides of the nose, forehead and cheeks.

Itching eye lashes. Many times the eyelashes are thinning and falling out.

Itching eye brows.

Excess facial oils.

Demodedic rosacea.

Swollen nose.

Is teenager acne also caused by Demodex Mites?

Yes, 90% of the teenagers acne is caused by Demodex mites, 10% is bacterial; the change of the hormones at that age makes the sebaceous glands produce more sebum, making the facial skin a perfect living and breeding place. They can now easily multiply and this is translated into infections and acne.

I have a greasy skin, will I always have acne?

No, a greasy skin does not mean you need to have acne, a greasy skin becomes only acne when there are infections, and the reason for the infections are most of the time Demodex mites.

If you eliminate the Demodex mites the infections will stop and your skin will get smooth and soft again, your pores will become smaller and an oily skin will be something from the past. Removing the Demodex mites will also reduce the infections from shaving to almost nothing.

Is it possible to have a problem with Demodex mites without knowing?

Yes, many people have problems, in one way or another, without knowing because there is not a lot of attention given to them by the medical profession in North America. The sooner that treatment is begun, the better your chances are to arrest the mites and prevent them from causing permanent damage.

Are Demodex Mites contagious?

Yes, Demodex mites are contagious but the parasites prefer a weakened immune system. This is one reason many partners who regularly sleep with their mates do not become infected. However, should the host be suitable, they are acquired through physical contact with infected persons; for example through kissing, hugging, using the same towels, etc. However, not everyone who is infected has problems with them. It is a fact that the majority of infected people show no signs of any disease from the infected people, only around 10% are getting skin problems. This may be due to a healthier immune system and/or because of numerous other reasons which are not so well known at this time.

Infected people with no visible signs can also transmit the mites to other people. Once infected, it can take months or even years before the signs of infection become visible.

Demodex mites and the beauty of your skin

Even when there are no visible signs of Demodex activity it is worth to treat yourself and eliminate the mites before it can become a disease.

A very common result from Demodex mites infection are widened pores, most of the time starting on the nose. Eliminating the mites with the Demodexin lotion will close your pores again and keep your skin healthy. Another common manifestation is skin flaking which accompanies the areas where the Demodex have infected and then moved on.

There are very good cosmetic products these days but what people doesn’t know is that you actually help the mites with them, good cosmetics contains a lot of nutrition and the mites are very happy with them.

Eliminating the mites first will improve your skin so much more, and the effect of your expensive cosmetics will be only positive, not helping the mites anymore to breed and damage your skin.

Losing eye lashes is also many times a result from Demodex mites' activity which are living in the roots of the eye lashes.

Why is it so important to do a test to see if you are infected with Demodex mites?

First of all, it is obvious that you would want to know if Demodex mites are the reason for your skin problem before starting the treatment. An accurate test will reveal the mites' presence.

We always advise people to be tested by a dermatologist who is experienced in this area. The treatment and follow up should be with the approval of the dermatologist. However, in the case where it is not possible to see a doctor, and you have access to a microscope, you can easily do the test yourself.

When the test is positive the person will be much more motivated to start and continue the treatment until the end. It is also necessary to do a test to find out if the mites are completely gone after the treatment, even when the symptoms are gone, otherwise the disease will start again.

How do I do the test (Information for the Dermatologist or yourself)?

In this section we will explain how to determine if you are infected with Demodex mites and how to find and count them. In this way you will be able to follow the progress of the treatment. It is important to do the treatment until the test result is negative and all of the mites are gone. Otherwise they will continue to multiply and the treatment must be repeated. It takes about 5 minutes for an experienced person to perform the test.

What you will need:

1. A microscope with a good lighting system and light condenser, a multiplication of 40 to 60 times is enough to detect them. In order to see more details you will need a magnification up to 400X.

2. A tool to scrape the sebum from the face and mix the obtained sample with the oil on the glass slide. There are some special tools sold for this purpose but anything will do, for example a little pointed knife, doesn’t need to be sharp; be careful not to cut your skin.

3. Household vegetable oil such as bean oil, grape seed oil, sesame oil, etc. to dissolve the sebum. Do not use liquid paraffin, glycerin, shampoo oil, etc.

4. Latex gloves to protect your hands from further infection from the mites, or latex fingers for the fingers you use to press the sebum out.

5. A small bottle for holding the oil and a pipette to put drops of the oil on the glass slide.

6. A disinfectant to disinfect the scrape tool.

7. Cotton balls to clean the tool.

What to do:

Taking samples in the different drops of oil and from different parts of the face will enable you to locate the originating areas of the mites.

1. First put three separate drops of vegetable oil onto a glass slide.

2. The doctor should sit face to face with the person and press the thumb and second finger on one side of the nose hard enough to squeeze some sebum out and scrape it off with the mite tool or something similar.

3. Put the obtained sebum in the first drop of oil and mix it so the sebum will dissolve in the oil and free the present mites, their larvae and eggs. Label the drop of oil with the specimen, according to the part of the face from which the mites were taken.

4. Do the same with the other side of the nose and put in the same drop of oil and mix.

5. Now press the top of the nose, scrape it and put the scraping in the same drop of oil and mix.

6. Clean and disinfect the mite tool.

7. Now scrape the forehead between the eye brows, stretch the forehead skin with your left hand up and starting in the middle of the fore head, scrape downwards to the beginning of the nose. Apply enough pressure so that you have a good sample. Do this a couple of times to ensure that you have collected enough to produce good results.

8. Put the obtained sample in the second drop of oil on the glass slide and mix with the oil and once again, disinfect the mite tool.

9. Now we have to obtain some sebum from the chin. Clench the jaw and facial muscles to create some tension on the skin of the chin. Scrape the skin starting from the lip down and apply enough pressure to obtain some sebum. Do this a couple of times in different directions.

10. Mix the obtained sample with oil in the third drop of oil.

11. Disinfect the mite tool for future use.

12. Place the glass slide under the microscope and examine the different drops one by one. Look very carefully and don’t use too much magnification in the beginning; 40 to 60X is enough. Increase the magnification after you find them and want to see more details. Adjust the light and focus as necessary to see the living and dead mites, eggs, nymphs and remaining bodies. Once you know what to look for, they become very easy to identify and the testing time will take only 5 minutes or so. Counting them will allow you to follow the progress of the disease by comparing the amount of mites with the future tests. Record the number that you find according to type: long (folliculorum) and short (brevis) from the different areas of the face (different drops of oil).

If you want to see them move the most dynamic temperature is between 28- 36 degrees Celsius, the minimum is 25 degrees Celsius. If necessary, warm up the glass slide in your hands. They can live away from the host approximately 36-58 hours in a drop of oil.

Larvae and nymphs never move but if you increase magnification you can sometimes see the mouth of the nymph moving. If you don’t find any then it is almost sure you are looking for the wrong things or you did the test incorrectly and need to do it over. Only discontinue the treatment when the test results are negative.

How to use the Demodexin lotion?

1. Before application, wash the face and hands with warm water and a neutral soap or better, a Whole Spectrum facial bar such as Orpheus or Paean. Wipe the face dry with a clean towel each time (a slightly moist skin can make the application of the lotion easier).

2. The easiest way to apply the lotion is to put some tiny little dots everywhere on the face with a finger and then gently rub the product into the skin, it is really not necessary to use a lot, just a tiny bit is enough. Repeat this procedure as often as possible but at least 2 times a day, one time in the morning and one time in the evening, the most important application is in the evening one. If it is possible to use more often reapply after the lotion is no longer evident and the skin is completely dry again. The lotion acts as a moisturizer and the skin will be soft and supple while the lotion is working. Once the skin becomes evidently dry, then reapply until dry again.

3. It is very important to cover the neck and upper chest and back area as well during the initial treatment phase as the mites will attempt to migrate.

4. It is a good idea to change out your linens each day to prevent reinfestation. Disinfecting thorougly your linens will help prevent the mites from re-infesting your skin.

Try to avoid the use of cosmetics as much as possible during the treatment. While using the lotion externally one can take 5-10 mg of vitamin B2 (riboflavin) 3 times a day at the same time, in addition, any product that can boost the immune system can be a help. Many customers have reported a change in diet is beneficial, reducing foods that weaken the immune system while increasing foods that strengthen the immune system.

Even if the symptoms are gone, don't stop treating, the duration of treatment at least 120 days for Demodex folliculorum, and at least 180 days for Demodex brevis.

Never use the lotion together with a pharmaceutical ointment at the same time, alternating use in the morning in the evening is ok. This lotion can only be applied externally, oral medication is not permitted.

How long must I continue the treatment?

You have to treat until they are all destroyed. This can only be seen by doing a test. Even if the symptoms have disappeared, it does not mean that they are completely gone. If you discontinue the treatment before the mites have been eliminated, they will multiply again very soon. The treatment can take up to one year, but you will see the results almost immediately and in most of the cases, when you also suffer from itching skin, this itch will stop after the first week or so.

To eliminate the long Demodex (folliculorum) you need continuous treatment for 120 days. For the short Demodex (brevis) it will take 180 days. Since without a test you never know if Demodex brevis is present it is advisable to treat always at least for 360 days to be sure they are all gone, however, the majority of the mites will be eliminated after one week.

Why does it take so long to eliminate them completely?

It takes so long because they are so difficult to reach and because the eggs and nymphs cannot be killed. Demodex folliculorum is the easiest to destroy because they live in the hair follicles and come regularly out of the skin to mate on the surface. Demodex brevis mites live deeper in the sebaceous glands and don't surface as often; they are much more difficult to reach, that is why Demodex brevis takes a longer time to eliminate. The ovum and nymphs are always in a deeper part of the skin and are covered with a membrane which nothing can penetrate except essential oils. The ovum and nymphs cannot be killed with pesticides, not with Ivermectin, mustard plaster or whatever. The time from copulating until a new generation hatches is between 15 to 20 days. So, it is very important to treat in a continuous way to catch the adults and prevent them from mating again.

Can there be setbacks?

Yes, it is possible to have setbacks even after several days or months of treatment. When the mites die, they decompose inside the skin and cause infection there. Different people have different levels of reaction to the infection. This is the most difficult period for acne and rosacea suffers, because they sometimes think that the treatment is not working, but on the contrary, it means that the lotion is working well and the mites are being killed. It is very important in this stage not to become discouraged and to continue the treatment without interruption. This period will last not long. Know that you skin will clear up and get better soon.

Can I use make-up while treating?

It is better not to use make-up or as little as possible while treating. The goal is to kill all of the mites. If you use make-up or something else at the same time, the action of the lotion is weakened and the treatment will be longer. Of course, if needed you can use make up once in a while.

Why the tickle does become worse in the evening and night?

Demodex mites are more active in the dark. They are genetically programmed to surface in the evening to breed, probably to increase there survival chances (host is sleeping). This explains why the tickle/itch gets worse in the evening. There is much more movement on the surface of the skin at that time.

Do I need to take vitamins during the treatment?

Yes, it is a help if you take 5-10 mg of vitamin B² (riboflavin) 3 times a day during the treatment, in addition, everything that can boost your immune system is a help.

How long do they live outside the body?

Demodex mites die soon in a dry environment. They can only live for a couple of hours away from the host. In a wet environment, like towel, this can be longer, and in a drop of oil for example they can live sometimes up to 58 hours.

Is there a need to take special precautions in the household while treating?

Not so much, Demodex mites will eventually die soon when away from the body, but they can sometimes live longer without a live host in a humid environment like towels etc., so always use your own towels and personal accessories; also try to change your pillow case every day and if possible your sheets as well.

Try to avoid contact with other infected persons even when they show no visible signs of having the mites; they can infect you again. If in doubt, your partner should also be tested for Demodex mites and if infected, do the treatment, otherwise you will become re-infected by means of physical contact, pillows, bedding, etc.

Please don't over react if your partner has no visible signs like acne, rosacea, itch, etc. In this case, wait first till the treatment improves you so you are sure Demodex mites were your problem, then later you can try to find out if physical contact with your partner makes you worse again and treat him/her if necessary.

Try to avoid facial contact with your pets and wash your hands after petting them.

What to do after the treatment?

Normally you don’t have to do anything. Gone is gone but it is easy to become infected again by contact with other people, towels, your partner (if not treated), beds, etc.

Sometimes there is a residual bacterial infection that is evident even if the mites are gone. Use one of the Paean products for bacterial infections caused by the mites or other reasons to eliminate this condition. For extra-sensitive skin sufferers use Charis facial products.

In addition, for long-time sufferers with damaged and/or scarred skin, use Dionysus products of clear up damaged and/or scarred conditions on the face caused by the Demodex mites.

Try to minimize physical face contact with other people and don’t use their personal things like towels etc.

It is a good idea to use one of the treatment products on some kind of regular basis before going to sleep to prevent them from returning like for example every other day only in the evening.

At the first signs of re-infection take a test as soon as possible. If the results are positive, restart and continue the treatment until the mites are gone again.

Can there be itching all over the body?

Yes, while demodex mites can live anywhere on the body where there are sebaceous glands, tickle and spots can occur on other areas of the body because of an allergic reaction by one’s immune system to infection from the mites, however, normally this can only happen when the immune system is really weakened, like for example AIDS patients. Acne on chest or back is more likely to happen because of Demodex mites.

Why they can not be treated effectively with pesticides etc.?

Human pesticides are harmful to the health of your skin and require in case of Demodex mites to a long period of treatment for your facial skin with generally poor results. The mites burrow deep into the tissue of the skin and are well hidden inside the hair follicles and sebaceous glands, making them very hard to reach. You cannot kill the eggs and nymphs because they are enclosed with a membrane that seals them well; also, pesticides can not penetrate this seal.

Using a pesticide a couple of times does almost nothing because you only kill the ones you can reach and every day new ones appear, ready to breed. The most successful approach is continuous treatment with a safe to use product. This assures that you are killing all of the mites as they come to the skin’s surface and over time it will take care of the ones who don’t.

Can Demodex mites cause problems in the eye lashes?

Yes, Demodex mites can cause severe problems in the eye lashes. Many woman are loosing there eye lashes because of Demodex activity, Extreme tickling, redness because of infections and even blepharitis. Only by treating the face to eliminate the Demodex mites is, most of the time, enough to get rid of this problem; in some extreme cases, additional treatment of the eye lashes can be necessary.

WARNING

As a matter of caution, never use any of the products from the website in your eyes or eye lashes. They are safe to use under your eyebrows and eye lids. Treatment of the eyes and the surrounding areas requires very careful use. You must first be examined by a physician who specializes in this field. Generally, a prescriptive ointment will be recommended. To repeat: Always consult with your physician before you use any kind of medication on your eyes.

My doctor tells me I am delusional?

This happens every day, except in Eastern Europe and Asia, almost all dermatologists in North Ameria don’t recognize or take Demodex mites into consideration when an itchy or crawling feeling on the face or/and scalp occurs. In the rare cases they indeed diagnose Demodex mites the only thing they can do is treating with pesticides who are poisonous and very bad for your skin. Most of the time, pesticides only help a bit and are not able to eliminate them completely so they just start to breed again and the symptoms stay. The reason why some people are getting troubles with those mites and others not is not well known, but has probably to do with a change in the immune system. Doctors simply don’t know how, or don’t want to test for those mites. It is a pity because it is very simple and takes only a couple of minutes. That is how it works in the Western medicine, if they can’t prove or they don’t know, it is not there, and sending the people home with the message they are delusional happens many times. Especially people with a lowered immune system can become suddenly a victim from those mites. If you have a facial skin problem and you are not sure if Demodex mites are the reason, it is a good idea to mail us first with the explanation and history of the problem, in that way we can help and advice you much better.

Dogs and red mange, infestation from Demodex mites

We are not familiar with treating pets but according to people who have already used our products to treat their dogs against Demodex mites, our products seems to work great, even better then the pesticides usually used for pets. If you want to treat your dog with non-poison safe lotion, this is the solution.

Demodicosis and Associative Diseases
Translation of a article published in "Bulletin of the Academy of Sciences of the Republick of Kazakhstan", 1992, No. 4, pp.84-88

Demodecosis as an independent disease has not yet well investigated. However, in the past decades the interest in this and other mites diseases has considerably grown (A.A.Antonyev et al.., 1988; R.D.Zhaxylykova, 1990)

The clinical picture of the demodicosis from the moment of infestation to development of various complications has not been adequately described. Moreover, up to now, the issue of pathogenic role of the mites Demodex upon the human beings remains disputable.

Material and investigation methods

In the laboratories, the Demodex mites were detected in almost all 6547 patients examined. In the investigation, we used the methods developed by our team (R.D. Zhaxylykova, 1990)

1: Direct micro scoping of the skin and mucous membrane surfaces in vivo by application of the adapted devices magnifying at least 50 times.

2: Rubbing in the pores of the skin with rapidly penetrating anti parasitics that cause destruction of the Demodex in the place of their habitat, and thereby release the allergenic components on which the local allergic reaction is being developed in the form of an edema of the connective tissue capsule, this leads to appearance of a visible papule - demodicosis focus. Moreover, we applied the universally known methods of scraping (B.P.Baksht,1966) and epilation (M.M.Mukhina, V.E.Yevseeva, 1980).

The 790 patients infected with Demodex were examined by the provocative method of detection of the Demodex colonies (R.D.Zhaxylykova, M.K.Kenenbayeva, 1990) Amongst the papules detected in all the patients examined, 873 colonies of the mites were subjected to enucleation and to subsequent micro scoping. In 93% of them were Demodex mites detected, in 0,4% - Sarcoptes scabiei, in 6,6% - colonies of by us, unidentified mites. Moreover, 10 persons with healthy skin were examined by, for us, accessible methods and in which the mites and their colonies not have been found.

A long-term dynamic observation was conducted over 342 patients infected by Demodex, infestation of these patients occurred through natural conditions more then 15 years ago till they became the sick persons with the laboratorial confirmed demodicosis. Besides that, demodicosis was also produced experimentally on a volunteer who had a healthy skin and on two cats which preliminary were thoroughly prepared for the experiment in witch the cats, during a period of tree months where bathed every day with soap and brush. Infestation of the volunteer was executed through the pre-boiled wisp of bast, on which the Demodex mites were taken from the "butterfly" region from the face a patient having laboratorially confirmed demodicosis on the face. By use of anti parasitics, there were 151 patients successfully cured who had various clinical manifestations and complications (so called clinical masks) /R.D.Zhaxylykova, 1990/ of the demodicosis (see Table).

Results of the investigations and discussion

Several investigators /A.K.Akbulatova, 1966; T.Rufli, G.Mumcuoglu, 1981/ marked in their papers at the high percentage of the Demodex infestation of the skin of the dermatologic patients and of "practically healthy" persons. We have a different point of view upon this fact. Among the infected by Demodex, in 62% of the examined persons there were clearly found expressed subjective sensations from the part of the skin. At the purposing questioning this percentage increased up to 84%. Periodical slight strokings, mainly of the face skin, scratchings that were observed in almost all examined patients allow us to speak about availability of the subjective symptoms in 100% of the patients under observation. Upon examining the subclinical and clinical manifestations of the demodicosis or its complications were found in all persons infested by Demodex. Absence of the mites in the skin of the examined persons with healthy skin testifies correctness of the clinical observations being carried out. Also this is confirmed by effective antiparasitic treatment of the patients, to which the specialists of different profiles gave different diagnosis. Absence or sharp decrease in percentage of detection of the mites in the skin of the treated patients (see Table) together with the positive dynamics of the clinical picture allow us to conclude as per their involvement in origination and development of the indicated diseases. However we consider necessary to continue investigations in this aspect with the acarological observation of the affected ("shock") organs and tissues.

As per mechanisms in development of allergic complications due to demodicosis, our points of view completely coincide with points of view and conclusions of the allergologists /V.I.Pytsky, et al.,1984/. Long-term, let it be even symbiotic (as the dermatologists and some other specialists consider) presence of Demodex in the human being skin pores in considerable amounts (from 1 sq. cm of the skin there were picked out up to 500 specimen of the Demodex /Yu.S. Balashov, 1982/) may cause sensibilization of the host`s organism. Effectiveness of the antiparasitic therapy makes it possible to conclude that over 151 years from the moment of detection in the glands of the skin of the human being in 100% of the examined persons the Demodex could transfer from the symbiotic to the parasitic mode of life. A similar phenomenon can be observed in the microcosm not infriquently /K.I.Skryabin et al., 1934/. This fact can explain the infectious nature, being found by the epidemiological investigators, of growth and dissemination of allergy and other, so called noninfectious, diseases /A.M.Vikhert, A.V.Chaklin, 1990/, some of which are listed in the Table given in this paper.

The demodicosis in 100% cases are inherited from the mother /Yu.S.Balashov,1982/. Our clinical observations have also shown 100% infestation by Demodex of the children of all ages beginning from the first days of their life. Therefore we consider that demodicosis and the associative diseases with participation of the Demodex began to affect the younger persons than it was earlier /K.S.Ternovoi et al., 1990/. Our investigations show that majority of the famous allergenes destroy the microscopic mites present in the organism of the patient with allergy. In this case a great amount of allergene components of the mites are being released, to which the host organism has been sensibilized. This fact was considered by us during treatment of the allergologic patients. For complete deliverance of the patients organism from the mites we used the "allergenic" for them earlier factors (food, medical preparations, pollen, etc.), which gave us possibility to reach complete liquidation of allergy in 91% of the allergologic patients. Diversity of clinical manifestations and complications of the demodicosis, from one part, may be the result of high self-organization of such microscopic organism as the mites Demodex /V.I. Zakharov, 1972/. From the other part, as it is known from literature, the mites can transfer on their bodies the smaller organisms: viruses, bacteria, fungi, etc. / Yu.S.Balashov,1982/. This may be the reason of development of the associative diseases, being caused, for example, by the Demodex and by the definite virus (including AIDS), by the Demodex and by the definite bacterium, etc. There may be very many such combinations, therefore clinical manifestations of the associative disease may be very different. Availability of the pricking-sucking-cutting mouth apparatus in the Demodex /Yu.S.Balashov, 1982/ promotes the appearance of the above-listed combinations of various associations (bacteria, viruses, etc.). Detection in one and the same patient of three varieties of the mites allows to speak about existence of the diseases caused by association of different mites with different microorganisms. The afore said may be added with information about high invasiveness of people to helmiths /N.N.Glamazanova, 1987/. Taking into consideration the above-mentioned data there may be supposed a possibility of wide spread of associative diseases, in which the Demodex may be an active etiological component. The high percentage of invasiveness of the skin and mucous membranes by the Demodex together with the available information in the literature gives us possibility to ascertain the availability of the demodicosis pandemic. It would be more correct to say about the pandemic of the associative diseases, in which the Demodex is the etiologic connecting base.

The demodicosis, that is not taken into consideration in the medical practice, considerably complicate the cause of famous infectious and noninfectious diseases. Availability of pandemic of the demodicosis and the associative diseases requires consolidation of the efforts of biologists, parasitologists, veterinary and medical specialists for liquidation of all manifestations and complications of these diseases.

In the original this paper was published in the journal "Bulletin of the Academy of Sciences of the Republic of Kazakhstan", 1992, No 4, pp.84-88.

Demodexin ingredients: 100% NATURAL NON-TOXIC, 2.5% ACTIVE INGREDIENTS: ESSENTIAL OILS, BASE: ORGANIC JOJOBA EMULSION

TESTIMONIAL BY JH (March 10, 2013): Here is some of my history with the problem and products I’ve used:

I have used the demodexin crème since last February 2012. When I started it I had already been using apple cider vinegar in the evenings when I could feel the crawlies. I noticed a difference soon with he demodexin crème, but I had much more eruptions that literally were like ‘holes’ starting in my skin….something I’ve never had at all. I called Michael he said the mites were escaping from under my skin to get away from the crème’s toxin. I kept using the crème.

When the holes came it would take about 4 -5 days for them to heal again, while using the crème, and picking off the white ‘mass’ which is the mite debris. The only thing that would keep the healing spots ‘soft’ to not be like a hard scab…was using the Charis Step 2 cleansing hydration, and I did not use it to wash, just to cleanse by rubbing into area, which kept the skin and healing all soft, much better during healing. And I wanted to allow for the hole to close on it’s own so that the mites would continue to flee. I used the crème all around hair line, in eyebrows, all neck, and all over chest, because the mites will go and hang out somewhere and then come back when/if the skin is habitable again.

The main area I noticed for al these months and still have it slightly is the ‘white debri’ mimics he skin so much it looks like real, but just underneath even a tight healthy pore was a film so slight going from check to check and all over nose. I have removed a layer almost every day since last February. It is NOT skin, so pushing it out, scraping then putting more crème---I have done this an average of 3-6 times per day, plus at bedtime and morning right away for all these months….not missed 1 day.

In May my skin had terrible eruptions and I hibernated in the house doing work but not going out.

Also, ALL this time I used antibiotics every day most days because the holes could get bacteria, and I needed to use the medication to reduce the breaking up of the skin and possible infection that ‘they’ call rosacea.

The main area mites are very resistant to leave is the nose, under nose….the crème there can wear off much more quickly, and even 1 week not paying attention to that area in particular I see they are making headway.

I feel one or two while sitting here, but I scratched and that must kill them because scratching the skin there stops the crawling feelings right away.

I have spent 1 or more hours every single day on this since last February. I have changed my pillowcase every single night too. I keep a stack of 10 in a basket by the bed.

I also used the scar oil—charis step4 sensitive skin repair serum. I use on all spots, holes, or wrinkles on my face. I have not kept any scar that if not using the holes would scar my light skin. There is a very vague shadow on one or two places that no one else would detect and those would have been scars if not for this scar oil.

Michael sent me ‘pure’ 100% demodexin oil without any dilution. I am putting it only on my nose area and the persistent place on my left cheek beside lips. This is a fatty part of the face. This is VERY potent oil that at first made me feel nauseated. It is a neurotoxin so I am careful to add to some emulsion. I believe it works as a added attack.

I am unsure if these will ever be completely gone, but I will use crème for my life I think. My skin that is unaffected glows and is radiant for my age look much younger and much of that is due to how great the crème is for ALL the skin. If I could use it all over my whole body I would, but the expense!!

So my only products from wholespectrum are:

Demodexin crème
Demodexin pure oil
Chars hydration milk step 2
Charis step 4 skin repair oil
Vitamin Enriched Facial Hydration Face Mist
The scrub pads (these help scrub out the mite debris)

If You are not allergic and can afford it, I would put 5 times the amount per day on your skin, use scrubbing pads to clean off dead skin cells and mite debri, (I also use a eyebrow pluckier to literally pluck out some debris on the skin during a breakout and then use charis crème to keep the place soft, then put on the demodexin crème, then the scar oil. I use all of them at once) I am very careful with the plucker and literally ‘pull’ off what looks like skin, but it is only debris escaping the skin…..15 years of this she*t. It is imperative to keep watching it every day as often as possible. I also pinch out the debris like they do when getting a facial. It’s all white and clearly not whiteheads.

I am not done, I have a thin layer still taking it slow (no other way anyway) and letting this come out a little bit every day.

I have not had to take any antibiotic for 2 months now at all. I have not had any holes or breakouts since 3 weeks and it was minor but still persistent mites in a panic hanging on.

I will never give up this fight, it is better and my skin looks great. I do know I have to continue for a while. Will keep in touch.

Let me know how you are doing. And thanks for emailing too.

Take care and Good luck!

TESTIMONIAL BY MR (January 18, 2013):

I am writing to tell you that I am having remarkable results using this lotion. I began using the lotion on November 13th and have used it twice a day since although I had to use it very sparingly in Maui (Dec. 17-Jan 9) as I was running very low.

My symptoms continued unabated for the first three weeks and my itch grew worse at night. It was terrible as I could not sleep. By the middle of December my symptoms began to diminish and with each day my results improved. Since I have been home (Jan 10) the last eight days I have been experiencing nothing short of a miracle as 95% of my symptoms are gone. My itch is almost non-existent and I can finally sleep. I have no face, nose, etc. irritation, no specs coming out of my pores, no new papules and pustules. I am so happy I almost can't believe my good furtune as my life has been hell for the past 1 1/2 year.

I know it is still early days but I have never experienced such a relief since I contacted demodex folliculitus and I just feel so very normal now; I am loving it. I will continue to use the lotion until it is all used up. My supply will probably last two more months at least.

I wanted to let you know my good news and to thank you. Will let you know how I am in two months time.

Thank you so much.

 



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